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No, it wasn't a dumb question at all...
You can build to your home park, but not to extremes. If the M's had 7 lefty hitters, they'd stomp people in Safeco, but pay too heavy a price on the road.
On the road is where you find out how good you "inherently" are ... if the M's 9 hitters, 5 left 4 right, are 100 OPS+ then they will hit that on the road, but might be 112 OPS+ in Safeco.
If the M's Safeco players are actually GOOD players, they'll be fine on the road. If they're Safeco-gimmicky players, then no.
Keep postin' my friend!