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I think it really depends on what you think you can get back in return for Lopez. As a a guy thats going to hit 20-25 HRs this season at 2B IN SAFECO he could be pretty intriguing to another club with more favorable dimension for Lopez's swing (and not too focused on OBP).
This is probably going to be a career high for him HR-wise in Safeco. You have to also consider Lopez's lousy OBP along with the good SLG, the high number of DPs (20 this year) and the likelyhood of Lopez not aging well defensively at 2B.
I think 15-20 HRs is much more likely in '10 than 25-30 HR considering Lopez's lack of raw power and career highs in ISoP and HR/FB this year. Even so I'd be pretty intrigued with Lopez at 3B. I think he profiles there MUCH better than at 2B defensively.
For me it depends on what kind of return you can get for Lopez.  Here you have a league-average 2B at bargain prices, but whose stock is probably at its high point. Will kind of talent would teams be willing to give up for him?