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I'll side with my favorite interim manager on this debate, unless there's a compelling body of statistical evidence otherwise. I think fatigue with MLB players is way over-played.
Mental fatigue I could sorta buy into. Maybe. You get a bit homesick, or tired of living out of a suitcase.
Physical fatigue, I really doubt it. Prince Fielder's production hasn't tailed off. Neither has Sabathia's...