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I think you could seriously mess with guys like Mauer and Ryan Howard by pitching them predominantly inside. FORCE those guys to react quicker and they'll be less effective.
Pitchers tend to pitch dumb sometimes. Despite the fact that Mauer eats fastballs on the outer end of the plate, pitchers pitched him MORE often to that part of the zone last year than your average lefty hitter.
Ibanez actually isn't an oppo hitter at all (asides from statistical blips in '02 and '09). All of his production is to right and right-center.
759 OPS career left
987 OPS to center
1.012 OPS to right
His swing was perfect for Safeco.