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For example, you could take the #5, #10, #15 ... #50 hitters in the NL and AL, and gather their performances against pitchers with low ERA's.
There is some site that runs splits vs. pitchers with low and high ERA's, isn't there? ESPN used to run them against power and soft-tossing pitchers and, of course, vs. GB/FB pitchers. But I thought I saw someplace that had year-end splits against lo/mid/hi ERA, too...