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It really depend on league type. Are you talking AL-only non-auction leagues? It would depend on scoring categories, points/roto, teams, positions, etc.
Would pass on Fister/Vargas/Pauley in almost any type of league though at those prices. Felix at $30 makes sense depending on league factors.
In general you don't want to pay for guys that hit close to their best case scenarios in the year prior (especially lower end talent). Its nearly impossible to make profit that way.