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Someone like Ogando, pitching for the Rangers, is definitely worth the risk. Obviously, any one-start week that results in a loss is probably going to net you negative points, but a bad outing from a closer hurts just as much as a loss from a SP (and oftentimes BSv's also lead to L's).
Saves are completely unpredictable. Cleveland went 4-2 last week, and still their ace closer only pitched 2.1 IP. Even when a team is hot, you can't predict if there will be save opportunities and that's really the only situation that a RP will be netting enough points to compete with a start.
Your everyday 6 IP, 2-3 ER, 4-6 K quality start is going to be worth 20+ points. No RP in any given week can be assumed to score that high. If you have a SP who can be reasonably expected to score a QS in most starts (and I think Ogando qualifies), he should be active over your third best RP.
Obviously, if you don't have a quality SP to step in, you do whatever you can to field a full active roster. But if you were to put Ogando on the trade blocks, have a feeling you could get back any closer in the AL you want - but again, probably wouldn't be smart to do that type of trade even if it was available.